Suggesting alternative route options, airlines, or a business frequent flyer membership that you haven't taken advantage of to maximise benefits to your company.
Using the power of an advance purchase strategy to ensure you get the best deal. Most airlines release advance purchase fares or sale fares months ahead of time. The savings on domestic airfares are considerable, even with purchase policies such as 14 days +. Your travel manager can work with you to set an air travel policy that makes the most of early airfares.
When you travel is also important. Consider seasonality and peak travel times, such as school holidays which inflate the demand and cost of air travel. It is even worth checking which day you travel - Tuesday is the new Monday in business travel with so many people working from home Mondays, which means Tuesday to Thursday are the peak days for domestic travel. The time of day also matters! It really is true that the early bird gets the worm, it is much cheaper to travel at 6am then 7:30am.